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ey0017.5-10 | Novel Receptor Signaling Mechanisms | ESPEYB17

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

S Nishimori , MJ O’Meara , CD Castro , H Noda , M Cetinbas , J da Silva Martins , U Ayturk , DJ Brooks , M Bruce , M Nagata , W Ono , CJ Janton , ML Bouxsein , M Foretz , R Berdeaux , RI Sadreyev , T Gardella , H Juppner , HM Kronenberg , MN Wein

To read the full abstract: J Clin Invest 2019;129:51875203.In brief: This report establishes inhibition of salt-inducible kinases as a central mechanism by which the parathyroid hormone 1 receptor (PTH1R) exerts its effects in both growth plate chondrocytes and osteoblasts/osteocytes during skeletal development, growth, and remodelling.Commentary</e...

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ey0016.15-15 | (1) | ESPEYB16

15.15. Irisin mediates effects on bone and fat via [alpha]V integrin receptors

H Kim , CD Wrann , M Jedrychowski , S Vidoni , Y Kitase , K Nagano , C Zhou , J Chou , VA Parkman , SJ Novick , TS Strutzenberg , BD Pascal , PT Le , DJ Brooks , AM Roche , KK Gerber , L Mattheis , W Chen , H Tu , ML Bouxsein , PR Griffin , R Baron , CJ Rosen , LF Bonewald , BM Spiegelman

To read the full abstract: Cell. 2018 Dec 13;175(7):17561768.e17.Irisin, a cytokine secreted by muscle during exercise, effects bone resorption and the differentiation of preadipocytes into thermogenic brown fat cells by displacing tethers between the cell and extracellular matrix molecules. Physical activity can reverse age-dependent decline in skeletal muscle, preventing osteopor...

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ESPE Yearbook of Paediatric Endocrinology

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

15.15. Irisin mediates effects on bone and fat via [alpha]V integrin receptors

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